Heredity
For some people, depression is in the genes. People with relatives who suffer from depression are more likely to also get the disorder.
Abnormal Levels of Neurotransmitters
Neurotransmitters like serotonin and endorphins are chemicals in the brain that affect mood. While scientists don't know how these biochemicals cause depression, when antidepressants that stabilize serotonin levels are administered, the symptoms are reduced.
Physical Changes of the Brain
High-tech imaging of the brain provides evidence that depression causes physical changes in the brain. How these changes cause depression is not yet understood.
Hormonal Imbalances
Hormones like estrogen, progesterone and testosterone can affect moods also. Scientists feel that changes in hormonal levels cause depression because twice as many women as men are treated for the disorder.
Personality Traits
People who are pessimistic or melancholy, or have low self-esteem, are more susceptible to depression.
Environmental Factors
Some researches think that people who have a serious illness, financial difficulties, or a stressful or demanding career or home life, are more like to suffer form depression.
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