Toenail Fungus Medications & Warnings
Toenail fungal infection is caused by organisms that thrive in a dark and moist environment. They may cause the toenail to become brittle and discolored. There are several types of toenail fungus medication, but there are some known side effects with its use. Most medications for toenail fungus infection are available as prescription drugs because of these side effects. Their use always comes with a warning before intake of these medications.
Terfinabine (Lamisil)
Lamisil works to inhibit the growth of fungi on the toenail by preventing the enzymatic activity that builds the fungal cell wall. Without the cell wall, it is difficult for the fungi to grow and multiply. It works best against Trichophyton rubrum and Trichophyton mentagrophytes, which are the two major causes of toenail infection.
Lamisil can cause stomach upset such as indigestion or dyspepsia. It may also cause headache and rashes. It also has the potential to cause liver disease and is highly contraindicated among people with liver disorders. In some cases, Lamisil intake may reduce the amount of white blood cell production in the body. These are antibodies that protect the body against infections. Users may also be at risk for development of Stevens-Johnson Syndrome, as well as toxic epidermal necrolysis. Skin blisters are also common.
Griseofulvin (Fulvicin)
The U.S. Food and Drug Administration rates Fulvicin as a category C risk for pregnancy. There is a possibility for birth defects to occur once taken during pregnancy. It is also associated with causing low sperm count. Allergic reactions may occur manifested as hives, breathing difficulty and swelling on the face. Vomiting, diarrhea, irregular menstrual cycle, insomnia, tingling sensation and numbness on the hand and face, and confusion may also occur. Drug interaction is also expected with Fulvicin, and intake of another prescription drug is contraindicated.
Itraconazole (Sporanox)
The National Medicine of Drugs indicated some minor side effects with use of Sporanox. These include constipation, diarrhea, stomach upset, gas pain, bleeding gums, muscle pain, sweating, dizziness, depression and nervousness. To a more serious degree, Sporanox may cause fever, chills, pale stools, painful or frequent urination, numbness of hands and feet, itching, rash and hives, according to Greg C. Elwood's article "Dangers of Toe Fungus Medication." Intake with other medications such as guanidine, dofetilide and levomethadyl may cause life-threatening side effects. It may also increase the blood sugar level when taken with medication that has itraconazole and protease inhibitors that may also increase the susceptibility to congestive heart failure.
Fluconazole (Diflucan)
Common adverse effects reported with Diflucan intake involve headache, abdominal pain, nausea, dyspepsia, diarrhea and taste perversion. Hepatic reactions may also occur that may result in jaundice and hepatitis. Fatal consequence is liver failure, according to RxList.com.
Precaution
Toenail fungus medications are prescription drugs because of the risk for adverse effects. It is important to read the warnings printed on the medicine package before intake and to take the medicine according to the proper dosage prescribed by your physician.
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